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CCK-induced Fos expression in brain stem is enhanced after intestinal nematode infection in rats. On the other hand, cholecystokinin CCK plays a pivotal role in the regulation of intestinal motility. Mast cells contact vagal afferent nerve fibres. Intestinal signals reaching the brain through the vagus nerve and involving neuropeptides such as CCK, play a role in the control of food intake. A direct action on sensory nerves? The perinatal period is characterized by a strong plasticity of physiological systems explaining the higher individual sensitivity to environmental factors foetal programming. Role of the digestive afferents in food intake regulation.
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